Natural Options that Reverse Symptoms

Category: Parkinsons Disease Information (Page 2 of 16)

Access 20 years of research focused on identifying natural approaches, therapies and treatments that offer the opportunity to celebrate relief from the symptoms associated with a diagnosis of Parkinsons disease.

Top Recommendation of a Treatment for Parkinsons

Studies have now systematically documented over 120 natural therapies that offer relief from symptoms of Parkinson’s disease to one extent or another. After over two decades of conducting research focused on Parkinsons, what is my top recommendation of a treatment option for Parkinsons?

My answer: photobiomodulation (light therapy). Why?

The gold standard company that first invented photobiomodulation devices beginning in 2016 is Vielight.com. Twenty-five studies have now been published using a Vielight photobiomodulation device. Every single study reports significant findings for a surprising variety of conditions including Parkinsons and Alzheimers.

I first learned about the Vielight photobiomodulation devices from interviewing Vielight’s CEO Dr. Lew Lim in 2018. At that time there was only one published study that reported significant findings for a sample of 5 subjects with early Alzheimers. Today there are 25 published studies using one of the Vielight devices.

Eight years later, hundreds of members of the Parkinsons Recovery audience have used the Neuro Gamma Vielight device. Feedback I have received has been consistently favorable which is why I rank their device as my top recommendation as a treatment for Parkinsons.

There has been an explosion of studies that evaluated photobioomodulation for one condition or another. Fifteen hundred studies that focus on photobiomodulation alone have been published since January, 2025.

Vielight offers a generous warranty on their photobiomodulation devices. If a user does not celebrate relief from symptoms they had anticipated within six months of use, they need only return the device for an 80% refund!

Only 10% of individuals in my audience have returned their device for a refund. The risk of getting one of the Vielight devices is clearly minimal given their generous 80% warranty offered by no other company.

Vielight (https://www.vielight.com) also offers members of the Parkinsons Recovery audience a 10% discount on any of their devices with the coupon code healing4me. Keep in mind that everyone in the family can use the device, not just the person who confronts neurological challenges.

A study published in 2026 offers groundbreaking evidence that the Vielight devices make the brain more resilient. Each of their devices include a helmet that emits the light and a nasal applicator that sends the light through the blood stream. A brief summary of this new study follows.

The Brain Becomes More Resilient with Photobiomodulation Home Treatments

A 2026 published study evaluated the effectiveness of a Vielight photobiomodulation device using a treatment group and a control group, the gold standard for any study. The study population consisted of active, healthy NCAA Division I collegiate football players over the course of their season. The treatment group administered the Vielight photobiomodulation at home three times a week. The control group wore an identical device that delivered no therapeutic light.

Both groups of players were subjected to head traumas from falls and other injuries typical of any college football season.

The active group showed no significant increases in inflammation or axonal remodeling markers in their brains while the control group exhibited significant increases.

This is truly a ground breaking result. Instead of always treating head traumas when they happen (such as head traumas to college football players or persons with Parkinsons), photobiomodulation makes the brain more resilient, better able to withstand repeated traumas to the head.

Some people who experience Parkinson’s symptoms fall frequently, causing repeated injury to their body and head. Making the brain more resilient makes it possible to avert problematic symptoms that result from repeated falls.

Studies using the Vielight devices using Parkinson’s subjects and Alzhiemer’s subjects have documented significant outcomes from regular use. This is still another reason why I make the Vielight photobiomodulation devices my top recommendation as a therapy to address symptoms of both conditions.

The Neuro Gamma device is recommended for persons with Parkinsons. The Duo device can be used if sleep and/or memory are also issues in addition to other Parkinsons symptoms.

Robert Rodgers PhD
Founder 2004
Parkinsons Recovery®
https://www.parkinsonsrecovery.com
robert@parkinsonsrecovery.com

Herbs Can Be Treatments for Parkinsons

Often the simplest solutions are the best. Research below finds herbs can be treatments for Parkinsons, in particular rosemary, sage and lavender The cost is minimal and the potential value in offering temporary symptom relief is high.

Why Herbs Can Be Treatments for Parkinsons

Front Neurosci. 2022 Jun 28:16:909833.  Neuroprotective Potential of Aromatic Herbs: Rosemary, Sage, and Lavender

Abstract

Hundreds of millions of people around the world suffer from neurological disorders or have experienced them intermittently, which has significantly reduced their quality of life. The common treatments for neurological disorders are relatively expensive and may lead to a wide variety of side effects including sleep attacks, gastrointestinal side effects, blood pressure changes, etc.

Several herbal medications have attracted colossal popularity worldwide in the recent years due to their availability, affordable prices, and few side effects. Aromatic plants, sage (Salvia officinalis), lavender (Lavandula angustifolia), and rosemary (Salvia Rosmarinus) have already shown anxiolytics, anti-inflammatory, antioxidant, and neuroprotective effects.

They have also shown potential in treating common neurological disorders, including Alzheimer’s disease, Parkinson’s disease, migraine, and cognitive disorders. This review summarizes the data on the neuroprotective potential of aromatic herbs, sage, lavender, and rosemary.

Robert Rodgers PhD
Founder 2004
Parkinsons Recovery
https://www.parkinsonsrecovery.com
robert@parkinsonsrecovery.com

Studies Recommend Betaine for Parkinsons

Studies recommend Betaine for Parkinsons. Trimethylglycine (TMG) is also called glycine betaine. The name trimethylglycine signifies that it has three methyl groups attached to each molecule of glycine.

 Wheat bran and beets are a good dietary source of TMG, with smaller amounts available in other cereal grains. TMG can also be made in the body from choline, an essential nutrient found in eggs, soybeans and other foods.

Why Studies Recommend Betaine for Parkinsons

Trimethylglycine or TMG is a recent and potential  addition to a Parkinson’s treatment program.  It helps as an anti-oxidant, anti-inflammatory, detoxification and energy enhancement.

TMG is also called betaine because it was first isolated from sugar beets.  It is not the same however as betaine hydrochloride.

It is now part of all development programs.  A dosage to consider is 1000 mg daily for women and 3000 mg daily for men.  Children need less, depending on their size. Always consult with your doctor about dosages.

SOURCES OF TMG

Dietary sources of TMG.  The main foods high in TMG are broccoli, beets and many other vegetables.  Cooking does not destroy the TMG in vegetables.

The problem is that most people do not eat nearly enough of these foods to get a sufficient amount of TMG from their diet.  Even if you eat plenty of these vegetables, it is usually not enough.

WHY SUPPLEMENT WITH TMG?

TMG is excellent for the liver and for detoxification.  Stress, infections, inflammation and other disease conditions may use up the TMG the body makes, so more is needed.  Toxic metals and toxic chemicals require more TMG in our bodies for their detoxification and removal.

Toxic Metals Delete Availability of TMG

Mercury interferes with the natural TMG production in the body and thus increases the body’s requirement for TMG.  If you have silver/mercury dental amalgams, you also likely need more of it.  Mercury can contribute to hundreds of health conditions.

Copper toxicity interferes with the production of TMG in the body and increases the need to supplement  it.  One cause of the copper toxicity is widespread zinc deficiencies in the soil and in food.  This tends to cause more accumulation of copper in the body.  Women tend to be more copper toxic than men, although it affects both men and women.

Cadmium also increases the need for TMG, either by interfering with its production or enhancing the demand for it in order to detoxify and remove cadmium from the body through the liver. Cadmium toxicity is very common. In part, this is due to widespread zinc deficiency in the soil, the food and in refined food diets.  The body takes up cadmium if there is insufficient zinc available in the diet.

Below find two studies that recommend Betaine (TMG) as a treatment for Parkinsons and other conditions as well.

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Curr Neuropharmacol. 2025 Aug 8. Betaine: A Promising Natural Product for Neurological and Psychiatric Diseases

Abstract

Neurological and psychiatric diseases pose a considerable global burden. Exploring additional potential prevention strategies and therapies is ongoing. As a prevalent natural product and nutraceutical from food, betaine’s pharmaceutical applications suggest benefits for both health and disease in multiple organs.

Recently, its efficacy on neurological and psychiatric health has been proposed and has drawn considerable attention. In addition to its well-known osmotic protection, due to methyl donation, it regulates metabolism, alleviates oxidative stress, and reduces inflammation. To manifest neurological and psychiatric health benefits, betaine acts by affecting gamma-aminobutyric acid associated with its transporters, related neurotransmitters, downstream and neurological pathways, and other specific mechanisms in the nervous system.

Betaine demonstrates therapeutic potential against various neurological and psychiatric diseases, such as epilepsy, neurocognitive disorders (including Alzheimer’s disease), Parkinson’s disease, stroke, multiple sclerosis, traumatic brain injury, depression, anxiety, schizophrenia, autism spectrum disorder, sleep disorders, fetal alcohol syndrome, syringomyelia, neonatal brain injury, neuropathic pain, and motor dysfunction.

Basic Clin Pharmacol Toxicol. 2023 Nov;133(5):485-495. Betaine-The dark knight of the brain

Abstract

The role of betaine in the liver and kidney has been well documented, even from the cellular and molecular point of view. Despite literature reporting positive effects of betaine supplementation in Alzheimer’s, Parkinson’s and schizophrenia, the role and function of betaine in the brain are little studied and reviewed. Beneficial effects of betaine in neurodegeneration, excitatory and inhibitory imbalance and against oxidative stress in the central nervous system (CNS) have been collected and analyzed to understand the main role of betaine in the brain.

What Makes Us Crazy

Two forms of energy dominate the universe as well as our bodies. The state of expansion and the state of contraction. Disease results when these two states become unbalanced which is what makes us crazy.

Our ancestors were unable to open up bodies. They instead became keen observers of our behavior. Two very different energies have been documented century after century. The Chinese refer to these two opposing energies as Yang (the state of expansion) and Yin (the state of contraction).

When neurological systems rear their ugly head, the two energies are unbalanced. Yang energy becomes the driving force of our life. What is wrong with Yang energy? Nothing! That is what makes us successful in whatever we choose to in our life. We focus, set goals and activate the energy required to manifest our dreams.

It is indeed difficult to surrender the get up and go energy that makes us successful in life. But when this expansive state dominates our life day in and day out, our neurons become stressed out and exhausted. It is this imbalance that is what makes us crazy as troublesome symptoms of Parkinsons surface.

While medicines and supplements thankfully suppress problematic symptoms, the solution to soothing overexcited neurons is to learn over time how to balance the two energies so that there is not too much Yang nor too little Yin.

The four seasons best describe the energetic state that is necessary to engage a successful journey down the road to recovery.

  • Summer: Mostly yang (expansion)
  • Fall: More in balance
  • Winter: More Yin (contraction)
  • Spring: Balance of two energies

Yang is known as hot energy. Yin is known as having cool energy. The liver (which gets overloaded with toxins with symptoms of Parkinsons and the brain are both considered the hot organs of the body.

Cooling down what makes us crazy requires an ongoing balance of the two diametrically opposed energies. Members of the Parkinsons Recovery audience tell me frequently that their symptoms seem to vanish for a day or week, then explode. It becomes a vicious juggling act.

What is happening here? The welcome relief surfaces when the two energies are at long last balanced: Not too much expansion nor too little contraction.

To summarize, we can always turn down the volume of what makes us crazy and frantic with confronting tremors that flare up and impaired mobility. It is not a question of medications or supplements. It is all about living a day to day existence that balances the “get up and go” energies with the “let go and relax” energies.

Robert Rodgers PhD
Founder 2004
Parkinsons Recovery
Road to Recovery from Parkinsons Disease
robert@parkinsonsrecovery.com

Lavender Calms Anxiety and Supports Sleep

Guess what. A treatment as simple as lavender calms anxiety and supports sleep. The plant also protects you from radiation exposure. This harmful exposure can be emitted by WIFI, cell phone towers, radiation treatments for cancer, smart phones or even new cars.

Energy healers will often recommend that their clients locate lavender plants in their home or office. Why? Lavender offers protection from EMF exposures. People report that they have more energy and feel better when placing a lavender plant next to their computer.

The plant can also be particularly helpful to persons undergoing radiation therapy.

If a plant dies, it has served its purpose. Do not hesitate to get a replacement.

The studies below report that lavender shuts down anxiety, promotes beneficial sleep and helps with depression.

Why not give a lavender plant an opportunity to serve a useful purpose? The cost is minimal. Potential benefits significant. Sometimes the simplest solutions offer the greatest benefits.

Three studies below confirm the benefit effects of lavender.

Asian Nurs Res (Korean Soc Nurs Sci). 2021 Dec;15(5):279-290. Effects of Lavender on Anxiety, Depression, and Physiological Parameters: Systematic Review and Meta-Analysis

Abstract

Purpose: The recent evidence suggested substantial anxiolytic efficacy of lavender. The aim of this study was to examine the efficacy of lavender for anxiety, depression, and physiological parameters and to elucidate the differential effects of lavender on anxiety and depression by study characteristics.

Methods: A systematic review and meta-analysis was performed following the PRISMA guidelines. We searched PubMed, Embase, Cochrane Library, Web of Science, and Cumulative Index of Nursing and Allied Health Literature databases for randomized controlled trials investigating the efficacy of lavender on anxiety, depression, or physiological parameters in humans. We assessed the risk of bias within studies with the revised Cochrane risk of bias tool for randomized trials. We used random effect model to estimate the average effect and computed bias-corrected standardized mean difference as effect size metric, Hedges’ ? for all outcomes.

Results: Lavender was superior to placebo or no treatment in reducing anxiety (Hedges’ ? = -0.72, 95% confidence interval [CI] -0.90 to -0.55, p value <.001), depression (Hedges’ ? = -0.43, 95% CI, -0.59 to -0.27, p value <.001), and systolic blood pressure (Hedges’ ? = -0.23, 95% CI, -0.41to -0.05, p value = .01). The moderator analysis by meta-regression indicated that route of administration accounted 6.5% (p value = .187) for the heterogeneity in anxiolytic effects, sessions of treatment accounted 13.2% (p value = .055), and participants’ health state accounted 8.9% (p value = .131) for the variance in anxiolytic effects.

Conclusion: Lavender aromatherapy showed substantial effect in reducing anxiety and depression, and sessions of administration increased the anxiolytic effects.

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Complement Ther Med. 2022 Sep:68:102832. The effect of lavender on stress in individuals: A systematic review and meta-analysis

Abstract

Background: Lavender is considered as one of the medicinal plants to manage stress. Although many preliminary studies evaluated the effect of lavender on individuals’ stress level, to the best of our knowledge, we did not find a study that summarizes the results. Therefore, the present study aimed to estimate the Pooled effect of lavender on the stress level of individuals using systematic review and meta-analysis.

Method: A systematic literature review based on PRISMA 2020 was performed on the SID, MagIran, Embase, PubMed, Scopus, Web of Science (WoS) databases, and Google Scholar motor engine using related MeSH/Emtree and ?Free Text words,? including “Lavender*”, “Lavandula*”, “Stress*”, “Stress Disorders, Traumatic”, and “Stress, Psychological” with no time limitation until August 2021: We also searched two Iranain free local resourses including MagIran https://www.magiran.com and Scientific Information Database (SID) https://www.sid.ir. The quality assessment of studies was performed using JBI checklist. Heterogeneity among studies was quantified using I2 index and Random Effects model was used to combine the data and perform the meta-analysis.

Results: In the initial search, 1520 articles were found. After excluding the irrelevant studies, finally, 21 articles with a sample size of 791 in the intervention group and 804 in the control group were included in the meta-analysis. As a result of combining the studies, stress score after using lavender in the intervention group showed a significant decrease of 0.63 ± 0.13 (95% CI) more than that in the control group (P < 0.001). The results of subgroup analysis demonstrated that the highest standardized mean difference (SMD) before and after the intervention in the intervention group compared to the control group was related to L. angustifolia species with 0.73 ± 0.22, student groups with 2.27 ± 1.34, and diagnostic tool of Perceived Stress Scale (PSS) with 0.82 ± 0.42, indicating that the difference between the groups was statistically significant (P < 0.001).

Conclusion: The pooled estimation of this systematic reiew and meta-analysis revealed that lavender significantly reduces individuals’ stress. Therefore, it seems that the use of lavender can be considered as a part of a stress management programs.

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Exp Gerontol. 2025 Nov:211:112919. A systematic review and meta-analysis of clinical trials on lavender for sleep disorders in older adult

Abstract

Background: The present study aimed to gather existing findings related to the effect of lavender on improving sleep disorders in older adults.

Methods: In this systematic review, PubMed, Web of Science, Embase, and Scopus databases were searched using keywords ((lavender OR Lavandula) AND (sleep OR insomnia OR “sleep disturbance” OR “sleep quality” OR “sleep disorder”) AND (elderly OR elder OR aging OR aging OR “older adult” OR geriatric OR geriatrics)) from their inception up to August 20, 2025. Only clinical trials evaluating the effect of lavender on aged patients (more than 60 years old) with sleep disorders were included. Then, data about drug formulation, dosage, duration of treatment, measurements, findings, and adverse events were recorded. A random-effects meta-analysis was used to calculate the pooled standardized mean differences (SMD) and their corresponding 95 % confidence intervals (CI).

Results: In this study, 84 articles were evaluated, and ten articles were selected for full review. In nine studies (90 %), lavender significantly improved sleep disorders. The most used scale among the articles was the Pittsburgh Sleep Quality Index (PSQI), which was used in seven studies (70 %). All the studies reported using lavender in the medicinal form of inhalation. The results of the meta-analysis indicated a significant improvement in the total score of sleep quality (SMD: -1.20, 95 % CI: -1.73, -0.68, I2: 87.5 %), with a more pronounced effect observed in studies that utilized the PSQI questionnaire.

Conclusion: Based on preliminary evidence from this review, lavender may effectively treat sleep disorders, especially in the elderly. 

Robert Rodgers PhD
Founder 2004
Parkinsons Recovery®
https://www.parkinsonsrecovery.com

Platelet Rich Plasma (PRP) Therapy

What is Platelet Rich Plasma (PRP) Therapy? When asked the question: What do Platelets in the blood do? Most people say they have one function: to clot the blood. This answer is correct, but it is a tiny fraction of the functions platelets perform for us and our body.

Platelet-rich plasma (PRP) therapy is a regenerative, minimally invasive procedure using a patient’s own blood platelets to accelerate healing in injured tendons, ligaments, muscles, joints, and skin.

It was originally used for musculoskeletal conditions (e.g., tennis elbow, arthritis), hair loss, and cosmetic facial rejuvenation but applications have spread to many other applications, including neurodegenerative diseases like Parkinsons where pain can affect symptoms. 

The process involves drawing blood, spinning it in a centrifuge, and injecting it into a part of the body that exhibits excessive inflammation.  The procedure promotes tissue repair and reduces pain. 

The procedure typically involves withdrawing blood from the patient which is then spun to create a concentrated body of platelets which are reinserted into the body. 

  • What it does: The high concentration of platelets (up to 10 times more than the concentration of platelets in a normal blood) releases growth factors. This  stimulates healing, reduces inflammation and supports tissue regeneration.

This concentration of platelets can be injected into places in the body that have a high inflammation and as a consequence pain.

  • The Procedure: A blood sample is taken from the patient, placed in a centrifuge for 15–30 minutes to concentrate the platelets, and then injected into the target area. Imaging guidance (like ultrasound) is often used for accuracy.

Research on Platelet Rich Plasma (PRP) Therapy

Neurochem Res. 2025 Mar 4;50(2):112. Systemic Rejuvenating Interventions: Perspectives on Neuroinflammation and Blood-Brain Barrier Integrity

Abstract

The aging process results in structural, functional, and immunological changes in the brain, which contribute to cognitive decline and increase vulnerability to neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and stroke-related complications. Aging leads to cognitive changes and also affect executive functions. Additionally, it causes neurogenic and neurochemical alterations, such as a decline in dopamine and acetylcholine levels, which also impact cognitive performance.

The chronic inflammation caused by aging contributes to the impairment of the blood-brain barrier (BBB), contributing to the infiltration of immune cells and exacerbating neuronal damage. Rejuvenating therapies such as heterochronic parabiosis, cerebrospinal fluid (CSF) administration, plasma, platelet-rich plasma (PRP), and stem cell therapy have shown potential to reverse these changes, offering new perspectives in the treatment of age-related neurological diseases. 

Research on Aspartame and Parkinsons

Nutr Neurosci. 2024 May;27(5):506-519. Aspartame use and Parkinson’s disease: review of associated effects on neurotransmitters, oxidative stress, and cognition

Abstract

Objective: The purpose of this review was to assess the current evidence regarding the associated physiological and cognitive effects of aspartame (APM) consumption and Parkinson’s Disease (PD).

Methods: A total of 32 studies demonstrating effects of APM on monoamine deficiencies, oxidative stress, and cognitive changes were reviewed.

Results: Multiple studies demonstrated decreased brain dopamine, decreased brain norepinephrine, increased oxidative stress, increased lipid peroxidation, and decreased memory function in rodents after APM use. In addition, PD animal models have been found to be more sensitive to the effects of APM.

Discussion: Overall, studies of APM use over time yielded more consistent results.

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Neurology. 2025 Oct 7;105(7):e214023. Association Between Consumption of Low- and No-Calorie Artificial Sweeteners and Cognitive Decline: An 8-Year Prospective Study

Abstract

Background and objectives: Consumption of low- and no-calorie sweeteners (LNCSs) has been associated with adverse health outcomes. However, little is known about the association between consumption of LNCSs and cognition. The aim of this study was to investigate the association between consumption of LNCSs and cognitive decline.

Methods: We conducted a longitudinal observational study using data from civil servants aged 35+ years at baseline who were enrolled in the Brazilian Longitudinal Study of Adult Health and evaluated across 3 study waves (2008-10, 2012-14, and 2017-19). Participants with incomplete dietary data, extreme caloric intake (<1st percentile or >99th percentile), and incomplete data for cognitive tests and covariates at baseline were excluded. A Food Frequency Questionnaire was used to calculate combined and individual consumption of 7 LNCSs (aspartame, saccharin, acesulfame k, erythritol, xylitol, sorbitol, and tagatose). We estimated z-scores across 6 cognitive tests. The association of LNCSs with cognitive decline was evaluated using linear mixed-effects models.

Results: Among 12,772 participants (mean age 51.9 ± 9.0 years, 54.8% women, 43.2% Black/mixed race), the mean consumption of LNCSs was 92.1 ± 90.1 mg/d. Among participants aged younger than 60 years, consumption of combined LNCSs in the highest tertiles was associated with a faster decline in verbal fluency (second tertile: ? = -0.016, 95% CI -0.040 to -0.008; third tertile: ? = -0.040, 95% CI -0.064 to -0.016) and global cognition (second tertile: ? = -0.008, 95% CI -0.024 to 0.008; third tertile: ? = -0.024, 95% CI -0.040 to -0.008). There was no association between tertiles of LNCSs and cognitive decline in participants aged 60+ years.

Consumption of aspartame, saccharin, acesulfame k, erythritol, sorbitol, and xylitol was associated with a faster decline in global cognition, particularly in memory and verbal fluency domains. Consumption of combined LNCSs in the highest tertiles was associated with a faster decline in verbal fluency and global cognition in participants without diabetes and faster decline in memory and global cognition in participants with diabetes.

Discussion: Consumption of LNCSs was associated with an accelerated rate of cognitive decline during 8 years of follow-up. Our findings suggest the possibility of long-term harm from LNCS consumption, particularly artificial LNCSs and sugar alcohols, on cognitive function. 

Robert Rodgers PhD
Founder 2004
Parkinsons Recovery®
https://www.parkinsonsrecovery.com

The Reason for Mobility Difficulties

When I ask people if walking is improved when they are in nature, the answer 100% of the time is yes. Why should hanging out in nature be such a tremendous support to rock solid walking?

The straightforward answer is – nature helps ground our energetic system.

As I describe in the video – problematic walking is directly connected to energy which is top heavy. Effortless mobility requires that our energy be distributed evenly from our head to our feet. When more energy is circulating around our head and the top of our body we become top heavy and are much more likely to fall, stumble and freeze.

The one criteria for energy healers to help their clients manifest improved mobility is for them to become grounded. If their energy is running haphazardly from left to right or spinning at the top of the body, they will simply exaggerate the problems a client confronts.

Another way of understanding what it means to be grounded is to “be in our body.”  When we reside only in our mind and brain with thoughts of worry and regret we are not grounded and will confront mobility challenges.

How to Become Grounded

  • Take off shoes and walk in the grass
  • Wear the color red
  • Spend your day out in nature as much as possible even if it means standing outside for a few minutes
  • Take off shoes when walking around your home.
  • Get grounding mats for your bed or a chair where you sit often
  • Use your intention to shift the energy from your head to your legs and feet.
  • Become mindful of each and every step you take.

Robert Rodgers PhD
Founder 2004
Parkinsons Recovery
https://www.parkinsonsrecovery.com 
Road to Recovery from Parkinsons Disease

 

Two Simple Suggestions to Support Recovery

What are two simple suggestions to support recovery from Parkinsons?The vast number of natural therapies documented by Parkinsons Recovery that support recovery is indeed overwhelming. So many choices! Which ones offer the greatest possibility of relief for you?

The challenge for everyone is that no option – whether a prescription medicine, surgery or natural treatment helps everyone celebrate recovery. Most people celebrate relief from symptoms for many of the options but not everyone. It comes down to the challenge of deciding which treatment options are most likely to benefit you.

Two Simple Suggestions to Support Recovery

I asked Dr. Bruce Fife, ND, to offer two (and only two) suggestions among the many that are available that he suggests would be most likely to benefit the most people. Here is his unexpected answer:

Might I add that the cost of these two suggestions is minimal relative to the anticipated benefit. I say go for it!

Robert Rodgers PhD
Founder 2004
Parkinsons Recovery®
https://www.parkinsonsrecovery.com
Road to Recovery from Parkinsons Disease

How to Identify Your Dominant Eye in 10 Seconds or Less

Here are your instructions on how to identify your dominant eye:

  • Put one hand in front of you.
  • Focus on an object like a picture (or a person) beyond you a short distance away.
  • Close one eye with the other hand.
  • Then close the other eye.
  • Notice what happens
  • When one of the two eyes is closed the object will be directly in front of you.
  • When the other eye is closed, the object will shift.

The dominant eye is revealed when your hand is directly in front of you. My dominant eye is the left eye which comes as no surprise to me. I have always been a right brain (big picture) person.

My eye classes prescription for long distance sight is stronger for my right eye and weaker for my dominant eye. Makes sense, eh?

What is the big deal here with whether one eye is dominate or not? Put a patch over your dominant eye, then challenge yourself with tossing a ball to another person. Having trouble? Then catch the ball. Having trouble? It is not so easy when your dominant eye is patched closed

Wobbly walking involving freezing and shuffling can be due in part to a stark difference between your dominant eye and your other eye. Equalizing out both eyes can boast rock solid walking.

Neuro-Optometrists can be of great assistance in this regard.

For more information about neuro optometry visit: https://noravisionrehab.org/

Robert Rodgers PhD
Founder 2004
Parkinsons Recovery®
https://www.parkinsonsrecovery.com

Swallowing Safely

Difficulty with swallowing safely is a typical symptom of Parkinson’s. How do you know for sure that you have a swallowing problem and if you do, what do you do about it?

Dr. Joel Herskowitz, M.D. and Dr. Roya Sayadi, Ph.D., authors of the just released book, Swallow Safely: How Swallowing Problems Threaten the Elderly and Others. A Caregiver’s Guide to Recognition, Treatment, and Prevention answer these questions and explain the critical role of swallowing safely for persons with Parkinson’s symptoms.

You can order Swallow Safely by clicking on Swallow Safely

Robert Rodgers PhD
Founder 2004
Parkinsons Recovery®
Road to Recovery from Parkinsons Disease
https://www.parkinsonsdisease.me

Jump Start Your Recovery in 2026 

The new year is the perfect time to jump start your recovery by assessing the underlying causes of neurological challenges you currently confront. In this spirit, I extend a warm invitation for you to enroll in my Jump Start to Recovery course that launches January 2026 and continues through February and March.
I will cover all of the cutting edge research discoveries that identify natural therapies proven to reverse Parkinson’s symptoms.

The purpose of my 2026 Jump Start to Recovery course is twofold.

1. Help you determine the underlying cause of your symptoms.
2. Identify therapies that address the cause to bring your body back into balance and harmony.

Visit the link below for more information and to register. Enroll today to take advantage of the early bird 50% holiday tuition.
https://www.parkinsonsrecovery.com/jump-start-to-recovery

Robert Rodgers, Ph.D.
robert@parkinsonsrecovery.com
Olympia, Washington
360-789-1658
Parkinsons Recovery®
https://www.parkinsonsrecovery.com

Broccoli Seed Tea

Below find directions for preparing Broccoli Seed Tea which contains the bioactive compound sulforaphane. This process involves a crucial two-step reaction using both broccoli seeds and ground white mustard seeds as a myrosinase enzyme source. 

Broccoli Seed Tea Recipe

Ingredients:

  • Dry, high-quality broccoli seeds: 1 tablespoon (or about 15g to 35g, depending on the desired strength)
  • Ground white mustard seeds (sinapis alba): 1/8 to 1 teaspoon
  • Water: Approximately 1 cup (or 100-200ml) 

Equipment:

  • A pot or microwave-safe container
  • A thermometer to monitor temperature
  • A means to strain the seeds (optional)
  • A blender (optional, if incorporating into a smoothie) 

Instructions:

  1. Heat the water: Bring water to a specific temperature. Research protocols suggest heating the water to approximately 60°C (140°F) to inactivate an enzyme (ESP) that reduces sulforaphane yield in broccoli, while preserving the added myrosinase later. Do not boil, as high heat destroys the necessary myrosinase enzyme.
  2. Combine seeds and water: Add the desired amount of dry broccoli seeds to the temperature-controlled water.
  3. Allow extraction: Let the mixture sit for about 10 minutes. This step helps extract the precursor compound, glucoraphanin, from the seeds.
  4. Add myrosinase source: Stir in the ground white mustard powder. This provides the active myrosinase enzyme needed to convert the glucoraphanin into sulforaphane.
  5. Activate sulforaphane: Let the mixture sit for an additional 10 minutes to allow the conversion reaction to occur.
  6. Consume: The mixture can be consumed as is, or strained for a clearer “tea” (though some fiber is lost). Many people blend the preparation into a smoothie with other ingredients like fruit, nuts, or protein powder to improve taste and texture. 

Early evidence suggests that this tea was most helpful for addressing non-motor symptoms including fatigue, sleep quality, and lack of motivation. Urinary incontinence and nocturnal urinary frequency showed significant improvement as well.

These symptoms are closely linked to energy production. This suggests that the primary effect of sulforaphane is to enhance energy production in neurons by reducing damage to mitochondria. Oxidative stress is likely to be the predominant mechanism in the development of the process that gives rise to these non-motor symptoms.

Research on Sulforaphane as a Treatment for Neurological Conditions

Nutrients. 2025 Apr 15;17(8):1353. Sulforaphane and Brain Health: From Pathways of Action to Effects on Specific Disorders

Abstract

The brain accounts for about 2% of the body’s weight, but it consumes about 20% of the body’s energy at rest, primarily derived from ATP produced in mitochondria. The brain thus has a high mitochondrial density in its neurons because of its extensive energy demands for maintaining ion gradients, neurotransmission, and synaptic activity. The brain is also extremely susceptible to damage and dysregulation caused by inflammation (neuroinflammation) and oxidative stress.

Many systemic challenges to the brain can be mitigated by the phytochemical sulforaphane (SF), which is particularly important in supporting mitochondrial function. SF or its biogenic precursor glucoraphanin, from broccoli seeds or sprouts, can confer neuroprotective and cognitive benefits via diverse physiological and biochemical mechanisms. SF is able to cross the blood-brain barrier as well as to protect it, and it mitigates the consequences of destructive neuroinflammation.

It also protects against the neurotoxic effects of environmental pollutants, combats the tissue and cell damage wrought by advanced glycation end products (detoxication), and supports healthy glucose metabolism. These effects are applicable to individuals of all ages, from the developing brains in periconception and infancy, to cognitively, developmentally, and traumatically challenged brains, to those in later life as well as those who are suffering with multiple chronic conditions including Parkinson’s and Alzheimer’s diseases.

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Biochem Pharmacol. 2025 Mar:233:116797. Sulforaphane: An emerging star in neuroprotection and neurological disease prevention

Abstract

Neurological diseases, including both acute injuries and chronic neurodegenerative disorders, represent major contributors to morbidity and mortality worldwide. Chronic neurodegenerative diseases, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), which require long-term management, present significant challenges in the search for neuroprotective agents with reduced adverse effects and enhanced therapeutic efficacy.

Sulforaphane (SFN), a bioactive compound found in cruciferous vegetables like broccoli and cauliflower, has garnered considerable attention for its potent neuroprotective properties and overall health benefits. Marketed primarily as a dietary supplement, SFN has shown a variety of biological activities and therapeutic potential in neurological diseases.

Recent surging studies including ours have highlighted its ability to impede the progression of AD, PD, and cerebral ischemia by fostering neurogenesis and inhibiting apoptosis, oxidative stress, and neuroinflammation. This review aims to summarize the latest research on SFN, exploring its advanced therapeutic potential and underlying mechanisms in various neurological diseases, offering a comprehensive overview for researchers focused on neurological pathogenesis and drug development in neuroprotection.

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Int J Mol Sci. 2020 Nov 16;21(22):8637. Efficacy of Sulforaphane in Neurodegenerative Disease

Abstract

Sulforaphane (SFN) is a phytocompound belonging to the isothiocyanate family. Although it was also found in seeds and mature plants, SFN is mainly present in sprouts of many cruciferous vegetables, including cabbage, broccoli, cauliflower, and Brussels sprouts. SFN is produced by the conversion of glucoraphanin through the enzyme myrosinase, which leads to the formation of this isothiocyanate.

SFN is especially characterized by antioxidant, anti-inflammatory, and anti-apoptotic properties, and for this reason, it aroused the interest of researchers.

The aim of this review is to summarize the experimental studies present on Pubmed that report the efficacy of SFN in the treatment of neurodegenerative disease, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple sclerosis (MS). Therefore, thanks to its beneficial effects, SFN could be useful as a supplement to counteracting neurodegenerative diseases.

Robert Rodgers PhD
Founder Parkinsons Recovery ®
https://www.parkinsonsrecovery.com

Hydrogen Therapy

Studies soundly conclude that hydrogen therapy has a bounty of benefits for persons confronting neurological challenges. Delivery of hydrogen by breathing it turns out to be a more effective delivery system than drinking water infused with hydrogen. Units are also less expensive.   

Benefits of Hydrogen Therapy 

The benefits of infusing your lungs with hydrogen therapy are extensive.

  • Enhanced energy
  • Reduced inflammation
  • Improved circulation
  • Better brain function
  • Faster healing
  • Reduction in anxiety

Admittedly this is a long list of benefits. What does hydrogen therapy do for you? It makes your mitochondria more efficient. This in turn increases the production of ATP, the energy “food” for the body.

A companion benefit is restoration of healthy bacteria in the gut. Healthy gut improves digestion and reduces constipation. 

In short, daily infusions of hydrogen offer a variety of benefits that can lead to a reduction in neurological symptoms.

Potential Issues with Hydrogen Therapy

If you are taking blood thinners, be sure to let your doctor know you are getting hydrogen therapy. It thins the blood and means you will need to take lower doses of the blood thinning medication prescribed by your doctor.

If you have a serious and chronic infection, best to put aside hydrogen therapy until the infection is cleared. The bacteria contain mitochondria as do all cells. Hydrogen therapy could potentially inflame the infection. 

About Hydrogen Therapy 

Here is the big picture. A company headed by an engineer has invented a machine that delivers hydrogen that you breath, not drink with hydrogen enriched water. www.h2biohacker.comThey report that breathing hydrogen for 3 hours a day for persons with Parkinson’s symptoms can offer welcome benefits.

The cost of their units are over 2,000 USD. I recommend you request a free consultation with Ben Tammetta, the CEO, to discuss this option further.  Ask if he will grant you a discount. A 10% discount code that may still work is drtalks

Abstracts on Hydrogen Therapy for Parkinsons 

Biomater Sci. 2025 Feb 11;13(4):896-912. Application trends of hydrogen-generating nanomaterials for the treatment of ROS-related diseases

Abstract

Reactive oxygen species (ROS) play essential roles in both physiological and pathological processes. Under physiological conditions, appropriate amounts of ROS play an important role in signaling and regulation in cells. However, too much ROS can lead to many health problems, including inflammation, cancer, delayed wound healing, neurodegenerative diseases (such as Parkinson’s disease and Alzheimer’s disease), and autoimmune diseases, and oxidative stress from excess ROS is also one of the most critical factors in the pathogenesis of cardiovascular and metabolic diseases such as atherosclerosis.

Hydrogen gas effectively removes ROS from the body due to its good antioxidant properties, and hydrogen therapy has become a promising gas therapy strategy due to its inherent safety and stability. The combination of nanomaterials can achieve targeted delivery and effective accumulation of hydrogen, and has some ameliorating effects on diseases.

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Mol Neurobiol. 2023 Apr;60(4):1749-1765. Molecular Hydrogen: an Emerging Therapeutic Medical Gas for Brain Disorders

Abstract

Oxidative stress and neuroinflammation are the main physiopathological changes involved in the initiation and progression of various neurodegenerative disorders or brain injuries. Since the landmark finding reported in 2007 found that hydrogen reduced the levels of peroxynitrite anions and hydroxyl free radicals in ischemic stroke, molecular hydrogen’s antioxidative and anti-inflammatory effects have aroused widespread interest.

Due to its excellent antioxidant and anti-inflammatory properties, hydrogen therapy via different routes of administration exhibits great therapeutic potential for a wide range of brain disorders, including Alzheimer’s disease, neonatal hypoxic-ischemic encephalopathy, depression, anxiety, traumatic brain injury, ischemic stroke, Parkinson’s disease, and multiple sclerosis.

This paper reviews the routes for hydrogen administration, the effects of hydrogen on the previously mentioned brain disorders, and the primary mechanism underlying hydrogen’s neuroprotection.

******

Mol Neurobiol. 2023 Apr;60(4):1749-1765. Molecular Hydrogen: an Emerging Therapeutic Medical Gas for Brain Disorders

Abstract

Oxidative stress and neuroinflammation are the main physiopathological changes involved in the initiation and progression of various neurodegenerative disorders or brain injuries. Since the landmark finding reported in 2007 found that hydrogen reduced the levels of peroxynitrite anions and hydroxyl free radicals in ischemic stroke, molecular hydrogen’s antioxidative and anti-inflammatory effects have aroused widespread interest.

Due to its excellent antioxidant and anti-inflammatory properties, hydrogen therapy via different routes of administration exhibits great therapeutic potential for a wide range of brain disorders, including Alzheimer’s disease, neonatal hypoxic-ischemic encephalopathy, depression, anxiety, traumatic brain injury, ischemic stroke, Parkinson’s disease, and multiple sclerosis.

This paper reviews the routes for hydrogen administration, the effects of hydrogen on the previously mentioned brain disorders, and the primary mechanism underlying hydrogen’s neuroprotection.

Robert Rodgers PhD
Founder 2004
Parkinsons Recovery
https://www.parkinsonsrecovery.com
Founder 2005
Alzheimers Recovery
https://www.alzheimersrecovery.com

Holy Grail for Parkinsons Disease

Symptoms of Parkinsons disease are troubling for everyone. The question I am asked more frequently is whether there ever will be a holy grail for Parkinsons Disease. Will a treatment ever be found that fixes everything?

Most people do not like my answer to this question. It would be so wonderful if a treatment could be found that would in fact fix everything. You have likely encountered websites and health care providers that promise to fix all of your problems.

The reason I know the answer to my question is no – there will never be a holy grail – is based on two reasons. I do not even like my answer, but here are the two reasons why.

First, there are a multitude of factors that cause the symptoms. Once a cause is identified (and there are usually many) it is then possible to identify treatment and therapies that can address it. But there will never be a treatment that fixes all of the causes. There are so many.

Say one of the primary causes for a person is toxins. There are many effective detox therapies that can address this particular cause. Detox protocols are not designed to address the challenge of persistent anxiety attacks or depression or trauma.

Second, I conduct a survey every holiday season which asks members of my audience whether they have been feeling better, the same or worse since the previous holiday season (a year ago). Results of my surveys over the years have been consistent. A third of respondents or more report feeling better.

I then ask respondents what therapies, treatments or steps have been helpful to them in feeling better. Does anyone report they found the holy grail that reversed all of their symptoms? No one reports this answer.

Persons who report feeling better report on average 6 different therapies or way that have embraced that are making the difference. These include a wide range of over 120 different natural options that have been proven to help people recover. It is the combination of methods that works the magic.

Summary

If you are frantic to find a holy grail for Parkinsons today, might I suggest you explore the potential causes of your symptoms first? That answer will guide your search for options that will make a difference to your recovery. Once the first cause is resolved, you are then invited to address a second or third cause.

The goal of course is the step back and realize you are getting better, little by little, day by day. The Road to Recovery is a process full of stops and starts. It is a journey that for whatever reason you have been invited to engage.

Robert Rodgers PhD
Founder 2004
Parkinsons Recovery ®
Road to Recovery from Parkinsons Disease
https://www.parkinsonsdisease.me

Olfactory Training

Has one of the treasured pleasures of life been lost. No longer able to smell a rose? Guess what? Olfactory training has been proven to reactivate the ability to smell.

What is Olfactory Training?

Olfactory training involved smelling distinct aromas such as rose, clove and eucalyptus several times a day for 10- 15 seconds per scent. It is recommended to take breaks between smelling the strong scents. As demonstrated in the review study below, olfactory training stimulates nerves in the nose to improve the brain’s ability to interpret and differentiate the varies aromas included in the training.  

J Clin Med. 2025 Sep 18;14(18):6578. Olfactory Training for Post-COVID-19 Olfactory Dysfunction: A Meta-Analysis of Efficacy and Combination Therapies

Abstract

Background/Objectives: This systematic review and meta-analysis evaluated the effectiveness of olfactory training (OT) using standardized protocols in patients with post-COVID-19 olfactory dysfunction. The objective was to assess whether OT, compared to no treatment, placebo, or alternative therapies, improved olfactory function as measured using validated smell tests, including UPSIT, Sniffin’ Sticks (TDI score), CCCRC, and B-SIT. 

Methods: A systematic search of PubMed, Web of Science, and Ovid Medline was conducted through February 2025 in accordance with PRISMA guidelines. Eight randomized controlled trials (RCTs) met the inclusion criteria. Data were extracted on study characteristics (author, year, country, design, sample size), population details (age, sex, post-COVID-19 cause), intervention type (training method, frequency, duration), comparators, outcome measures (baseline and post-intervention olfactory scores), follow-up duration, and reported adverse effects. Meta-analyses were performed using RevMan and Open Meta-Analyst. 

Results: OT significantly improved the olfactory scores compared to those of the controls. The greatest improvement was observed when OT was combined with PEA-luteolin (MD = 4.62, 95% CI: 2.17-7.06, p = 0.0002), followed by EDTA (MD = 2.33, 95% CI: 0.58-4.08, p = 0.009). Corticosteroids showed a borderline benefit (MD = 1.34, 95% CI: 0.01-2.67, p = 0.05), while alpha-lipoic acid had no significant effect. Combination therapies were associated with higher recovery rates (RR = 1.65, 95% CI: 1.13-2.42, p = 0.01). 

Conclusions: Olfactory training is an effective treatment for post-COVID-19 smell dysfunction. 

Robert Rodgers PhD
Founder 2004
Parkinsons Recovery ®
Road to Recovery from Parkinsons Disease
https://www.parkinsonsdisease.me

Say Goodbye to Dementia

Recent therapies make it possible to say goodbye to dementia.

Therapies to Sharpen Memory and Reverse Dementia

The number of new and innovative therapies that improve memory and cognition has skyrocketed over recent years. Many of them you have likely never even heard about. Recent research revelations are transforming how memory challenges can be successfully treated.

say goodbye to dementia

I warmly invite you to enroll in my new online course – Say Goodbye to Dementia. Cutting edge therapies are covered that nurture memory and support clear thinking. All recommendations are grounded in evidence based research.

The course includes a consultation with Robert Rodgers PhD, founder of Parkinsons Recovery. Family members are encouraged to participate in the consultations.

Click on the link below to claim the 50% tuition discount.
New Discoveries to Improve Memory

Robert Rodgers PhD
Founder 2004
Parkinsons Recovery
https://www.parkinsonsrecovery.com
robert@parkinsonsrecovery.com
Olympia Washington
360-789-1658.

Remedies for Loss of Smell

One predictor that an individual will develop symptoms associated with a diagnosis of Parkinsons is the loss of the ability to smell. Many people with Parkinsons believe that remedies for loss of smell do not exist. The belief is that once smell is lost it is a done deal.

I suggest the body can always recover problematic symptoms by identifying and addressing the root cause or causes. One deficiency documented to be deficient in persons with Parkinsons symptoms is zinc which – you probably guessed it – is related to a loss of smell and an increased risk of dementia.

Zinc deficiencies can also cause a compromised immune system, hair loss and even a loss of appetite. Adequate levels of zinc protect against oxidative stress and the aggregation of the protein alpha-synuclein.

Most importantly, zinc helps regulate blood sugar levels which have been found problematic in persons with Parkinsons. It reduces the impact of insulin resistance and helps improve regulation of sugar levels.

A word of caution. While too little zinc causes a variety of symptoms an excess could potentially be harmful, especially is applied through a nasal applicator. As with all supplemental regimens, balance is the key to recovery.

Two Other Remedies for Loss of Smell

Studies show a significant B12 and vitamin D deficiencies in persons with Parkinsons symptoms. Both are also implicated with an impaired ability to smell.

Summary

Eager to smell better? Talk with your doctor about treating deficiencies of zinc, B12 and Vitamin D by taking supplements or eating foods that contain them,

I predict you will be pleased with the outcome. After all, smell is one of the magical wonders of life.

Robert Rodgers PhD
Founder of Parkinsons Recovery and Alzheimers Recovery
https://www.parkinsonsrecovery.com
https://www.alzheimersrecovery.com
robert@parkinsonsrecovery.com
Olympia, Washington

Berberine

What Is Berberine?

Berberine is a natural compound found in the roots, stems, and the bark of various plants such as European barberry, goldenseal, Oregon grape, and tree turmeric. It also facilitates the production in the body of the AMPK enzyme found to be deficient in individuals confronting neurological challenges.

Available as an over the counter supplement in companies such as Life Extension for a modest cost.

Recent studies report a strong connection between insulin resistance and Parkinson’s symptoms. Berberine supports healthy blood sugar metabolism which is another reason why researchers are suggesting its beneficial effects for Parkinsons and Alzheimers.

Below are listed abstracts of recent studies that recommend Berberine as a treatment for neurological conditions.

Neurotox Res. 2022 Aug;40(4):1096-1102. Can Berberine Serve as a New Therapy for Parkinson’s Disease?

Abstract

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by dopaminergic neurodegeneration and deposition of alpha-synuclein. Mechanisms associated with PD etiology include oxidative stress, apoptosis, autophagy, and abnormalities in neurotransmission, to name a few. Drugs used to treat PD have shown significant limitations in their efficacy.

Recent focus has been placed on the potential of active plant ingredients as alternative, complementary, and efficient treatments. Berberine is an isoquinoline alkaloid that has shown promise as a pharmacological treatment in PD, given its ability to modulate several molecular pathway associated with the disease. Here, we review contemporary knowledge supporting the need to further characterize berberine as a potential treatment for PD.

Int J Clin Pharmacol Ther. 2025 Sep;63(9):432-438. Anti-neurodegenerative treatment in Alzheimer’s disease: Multifaceted mechanisms of action of berberine

Abstract

Background: Berberine, a traditional Chinese medicine, has demonstrated significant therapeutic influences in treating diabetes, obesity, and diarrhea, among other conditions. It has exhibited potential therapeutic benefits for various neurodegenerative diseases, namely, Alzheimer’s disease (AD), Huntington’s disease (HD), and Parkinson’s disease (PD).

Aims: This study aims to elucidate the mechanism behind berberine pharmacological action in treating AD.

Materials and methods: We search the articles published in PubMed and CNKI and summarize the mechanism of berberine in AD.

Results: In recent years, as research into the pharmacology of berberine has deepened, researchers have discovered its strong neuroprotective properties. The ability of berberine to enhance cognitive function is thought to result from inhibiting the spread of AD-related proteins, reducing oxidative stress and inflammation, increasing choline levels, and regulating autophagy.

Conclusion: This review explores the latest research on berberine in AD, suggesting that berberine and its analogs may offer a promising new approach to treating the condition.

Front Pharmacol. 2022 May 20:13:845591. Berberine: A Promising Treatment for Neurodegenerative Diseases

Abstract

Berberine, as a natural alkaloid compound, is characterized by a diversity of pharmacological effects. In recent years, many researches focused on the role of berberine in central nervous system diseases. Among them, the effect of berberine on neurodegenerative diseases has received widespread attention, for example Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and so on.

Recent evidence suggests that berberine inhibits the production of neuroinflammation, oxidative, and endoplasmic reticulum stress. These effects can further reduce neuron damage and apoptosis.

Chem Biodivers. 2025 Aug;22(8):e202500170. Unraveling Berberine’s Molecular Mechanisms in Neuroprotection Against Neurodegeneration

Abstract

Neurodegenerative diseases (NDs) exhibit significant global public health challenges due to the lack of effective treatments. Berberine (BBR), a natural alkaloid compound in various plants, has been recognized for its potential neuroprotective properties.

This review explores the current understanding of BBR’s mechanisms of action and its therapeutic potential in preventing and treating NDs such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease.

BBR’s neuroprotective properties are attributed to its multifaceted actions, including anti-inflammatory, antioxidant, antiapoptotic, and neurotrophic effects. In addition, BBR can influence many signaling pathways involved in neurodegeneration, including AMP-activated protein kinase (AMPK), nuclear factor erythroid 2-related factor 2, and brain-derived neurotrophic factor pathways. Furthermore, BBR targets vital signaling pathways, including AMPK, PI3K/Akt, and MAPK, which are essential for developing NDs.

In addition, BBR’s efficacy in reducing neurodegenerative pathology and improving cognitive function has been demonstrated through preclinical studies using cellular and animal models. Clinical trials demonstrating BBR’s therapeutic potential in NDs have yielded promising results.

Inflammopharmacology. 2025 Apr;33(4):2129-2150. Neuroprotective efficacy of berberine and caffeine against rotenone-induced neuroinflammatory and oxidative disturbances associated with Parkinson’s disease via inhibiting ?-synuclein aggregation and boosting dopamine release

Abstract

Parkinson’s disease (PD) is characterized by motor impairment, glial-mediated inflammation, redox imbalance, and synuclein aggregation. Conventional therapies relieve early PD symptoms, but they do not repair dopaminergic neurons.

Berberine (BBR) and caffeine (CAF), both natural alkaloids, exhibited neuroprotective effects in many neurodegenerative disorders. Consequently, we hypothesized that the combination of BBR and CAF therapies would offer protection against PD-related impairments in the rotenone (ROT)-induced rat model when compared to the commercial drug, metformin (MTF).

Results showed that the combined administration of BBR (25 mg/kg/day) and CAF (2.5 mg/kg/day) for four weeks prevented motor deficits, weight reduction, dopamine (DA) depletion, and monoamine oxidase (MAO) activity in ROT-induced rats in comparison with monotherapy of BBR and CAF along with MTF. This combination produced a notable neuroprotective effect by reducing tumor necrosis factor (TNF)-? and interleukin-16 (IL-6) in midbrain of rats. BBR and CAF combinations markedly normalized tyrosine hydroxylase (TH) levels and decreased total ?-syn and ?-syn-pser129 aggregation and increased protein phosphatase 2A (PP2A) levels.

Histological analysis indicated that damaged neurons exhibited significant amelioration with the co-administration of BBR and CAF. The molecular docking results indicated that both BBR and CAF had notable binding affinity for the protein pocket surrounding the ?-syn, PP2A, and TH in comparison to MTF. They are predicted to serve as effective inhibitors of enzyme-mediated phosphorylation of ?-syn-pser129.

Conclusively, combined BBR and CAF administration presents a novel strategy for neuroprotection by blocking the initial events in PD incidence, demonstrating considerable anti-oxidative and anti-inflammatory benefits relative to MTF.

Robert Rodgers PhD
Founder 2004
Parkinsons Recovery
https://www.parkinsonsrecovery.com
Road to Recovery from Parkinsons Disease
https://www.parkinsonsdisease.me

What Your Voice Says About You

Now here is something interesting to do, especially if you ever wondered what your voice says about you. It is called Nano voice and is available on the Sound Health Portal for free. Here is the link to get a free analysis of your voice.

https://www.soundhealthportal.com/nanoVoice/index.html

Once you land on the Nano Voice page above, click Start. Then, talk in a normal voice without pauses for 90 seconds. An analysis of the frequencies emitted by your voice will be instantly provided.

What Your Voice Says About You

Once you generate your first overview report, you can restart Nano voice and talk a second time for 90 seconds to generate a follow-up report. I talked for 90 seconds three times back to back. The three reports of my personality were all very similar. I must report they also described me to a tea.

Why bother?

  • It is free
  • It takes only 5 minutes
  • The instant report that is generated is fascinating

This short activity will convince you to take analysis of voice profiles seriously. Healing through sound (and light) is the medicine of the future

Robert Rodgers PhD
Founder 2004
Parkinsons Recovery
2025 Road to Recovery from Parkinsons Disease

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