Sharry Edwards pioneered a unique technology that falls within a field of complementary medicine that is called BioAcoustics. This innovative discipline combines Vocal Profiling through voice spectral analysis and the use of low frequency analog sound presentation to assist the body to support optimal form and function. BioAcoustics is to be considered a complementary modality.
Sound Health has discovered that the frequencies contained in the voice are holographic representations of your state of health and wellness. Every muscle, compound, process and structure of the body has a Frequency Equivalent™ that can be mathematically calculated.
Sharry Edwards has discovered that people with similar trauma, illnesses, syndromes, psychologies, diseases, toxins… have similar, if not identical, vocal anomalies.
Click the arrow below to hear my interview with Bill McAnalley PhD who discusses why food can fix things that drugs cant. His discussion focuses on explaining the causes of Parkinson’s and lists the foods needed to treat each cause.
Information about Dr. McAnballey’s company, is accessed by visiting Aroga
Below are the talking points that Dr. McAnalley prepared for my interview with him on Parkinsons Recovery Radio where he explains why food can fix things drugs cant
Parkinson’s disease (PD), characterized with bradykinesia, static tremor, rigidity and disturbances in balance, is the second most common neuro-degenerative disorder. Alzheimer disease is first.
With the global trends in aging, the incidence of PD has increased year by year and the prevalence rate is up to 12% among the elderly over the age of 65 years. So far, there is still no exact cure for PD due to its diversity of etiology and complexity of symptoms.
Currently, Parkinson’s disease is treated with Levodopa and maybe Monamine, Oxidase Inhibitors (MOAs) or Acetylcholine inhibitors. Levodopa makes more Dopamine available for the dopamine receptor, MOAs increase the amount norepinephrine, dopamine and serotonin at their prospective receptors and acetylcholine inhibitors make more acetylcholine available to its receptor.
None of which address the physical cause of the disease.
The cause of PD has not been completely elucidated, but it has been generally acknowledged that the improvement of oxidative stress is one of the most important patho-physiological mechanisms.
Dr. Bill’s research has focused on stopping the causes of diseases like Parkinsons by:
The inhibition of oxidative stress:
PD patients are in a state of oxidative stress. Oxidative stress is caused by the increase of free radicals in the organism, while the ability to eliminate free radicals is decreased at the same time. A large amount of lipid peroxide, such as Malondialdehyde (MDA), hydroxyl, carbonyl, etc., will cause cell death, which leads to neuronal apoptosis ultimately.
The mitochondria is the power plant and energy conversion station of cells. It also regulates the process of gene expression and apoptosis. Recent reports have suggested that mitochondrial dysfunction is closely related to a variety of neuro-degenerative diseases including PD.
The reduction of toxic Excitatory Amino Acids (EAA):
Glutamate (Glu), Also, gamma-aminobutyric acid (GABA) and enkephalin can can produce excitotoxicity effects on nerve cells. Glutamate creates an excitatory effect on nerve cells, and is toxic when Dopa Amine neurons are fully or partially degenerated.
The inhibition of neuroinflammation:
Neuroinflammation is a common and important pathological mechanism in nervous system diseases and different neurological diseases are involved in neuroinflammation at some stage. At present, it is believed that neuroinflammation was involved in an important cascade reaction in neuronal degeneration of PD.
When the central nervous system suffers from exogenous antigens stimulus, such as pathogenic microorganisms or foreign bodies, microglia will be rapidly activated. Then, the activated microglia cells can secrete various cytokines such as IL-1β, IL-2, IL-4, IL-6, TNF-α, and IFN-γ, etc. The cytokines cause neuroinflammation.
The inhibition of neuronal apoptosis:
Parkinsons is caused by the premature death of dopaminergic neurons by abnormal apoptosis activation. Energy for normal activities of brain cells comes directly from aerobic energy, and there is little energy storage. However once brain damage occurs, it will cause nerve cell apoptosis or death.
The Bcl-2 family of proteins regulate apoptosis. It is divided into two categories:anti-apoptosis gene (such as Bcl-2, Bcl-xL, Bcl-w, Bcl-1, etc.) and pro-apoptosis gene (such as Bax, Bak, Bad, Bid, etc.). Their ratio regulates apoptosis.
The inhibition of abnormal protein aggregation:
Mis-folded and aggregated proteins play a key role in the pathogenesis of Parkinsons Disease. Protein aggregates differ from disease to disease. This common characteristic shows that protein deposition is toxic to neurons.
Studies confirmed that the activity of the proteasome dropped substantially in substantia nigra of patients with PD, which weakened the ability of the substantia nigra to degrade α-syn and other proteins.
Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration:
Nrf2 is a basic leucine zipper (bZIP) protein that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress.
Listing of Foods that Can Fix Things Drugs Cant
The inhibition of oxidative stress:
Brahmi, Bacopa monnieri
Maca root powder, Lepidium meyenii (Walp.)
Tongkat Ali (Longjack), Eurycoma Longifolia
Turmeric root powder, Curcuma longa
The reduction of toxic Excitatory Amino Acids EAA:
Many people who experience symptoms of Parkinsons Disease engage an aggressive search for ways to reverse them. Secrets to healing are somewhere “out there” in the universe.
The belief is that most of the good answers are difficult to find. The journey for the right answers is much like a treasure hunt for a treasure that is buried in a secret vault – a Fort Knox of sorts that locks up all the answers for reversing Parkinson’s symptoms.
Sometimes the journey involves finding one solution after another. When one solution fails to produce desired results, a new solution or therapy is pursued. Some people chase after dozens of therapies. Results are often disappointing time and time again. The search for answers “out there” is exhausting!
Research can and does make a difference. Being better informed can and does make a difference to recovery. That is why I maintain the massive body of resources on options for recovery on the many Parkinsons Recovery websites I maintain.
There is a downside to a search “out there” somewhere for answers. It activates a continuous infusion of adrenaline. Adrenaline rushes are stimulating. They energize the body into action. The downside to adrenaline rushes is that the body has no energy or resources to produce dopamine. What is needed to reverse symptoms is to maintain a delicate balance of dopamine and adrenaline.
Recovery is Always Moving Toward You
There is a companion approach to a search for answers that offers the promise of marvelous results. Think about recovery as an opportunity that is always moving toward you. It is not something you have to discover by searching long and hard in places far away.
One of the seven secrets to healing a chronic illness like Parkinson’s disease is to listen to the messages your body is always trying to communicate to you. The body has a memory of the perfect state of wellness and health. Disease is not the body’s natural state. Health is. the body is always striving to reverse any disease process that causes neurological symptoms.
Your body is giving you important information every day. Perhaps your intuition tells you to stop dying your hair or stop using a particular shampoo or stop using laundry detergent that is toxic. Perhaps you always tend to discount the instincts about recovery that you get every day. When you begin to trust these instincts you may marvel at how much better you begin to feel.
Finding natural ways to die your hair is not a solution that is “out there.” It is right here!
Finding a natural shampoo without toxins is not a mysterious solution that is “out there” somewhere. It is right here!
Changing your laundry detergent is not a task that can be performed only by a rocket scientist.
You can do it – right now.
The reality is that recovery is staring you in the face every day. Your job is simple. Pay attention. Act on any and all intuitions that you get when you listen to your body.
The body has all the resources it needs to maintain the delicate balance of adrenaline and dopamine. You usually have to make some life style changes to give the body the support it needs. When the body has the resources it needs to maintain balance, symptoms will melt like an ice cream cone on a hot summer day.
The answers have been staring you in the face all along. They are not “out there.” They have always been moving toward you.
I know stress and Parkinsons disease is a major player in my symptoms. I have chronic pain and suffering from a surgery to my face that developed into what is referred to as a central pain disorder. Meaning, the central nervous system has become involved. I think it interesting that where this takes place is in the vicinity of the Substantia Nigra area of the brain where Parkinson’s develops. I’ve always thought there might be a connection.
I take 2 anti-epileptic (dangerous) drugs in order to function but this still leaves me with unbelievable discomfort that registers on my consciousness at all times. This, I see, as one of my greatest challenges to any kind of recovery. The others are :
Subtle stress in most everything I do (I just realized this) and
Negative thought patterns even though I see myself as a positive person.
I had childhood trauma and trauma as a young woman. I developed an autoimmune disease at age 22 that most often is not manifested in anyone younger than 50. I attribute this to a sensitive body that could not handle the devastation of estrogen packed birth control pills manufactured in the early 70’s.
Anita
My research concurs with both of your observations. Reducing anxieties and transforming negative thoughts offer welcome relief from symptoms of Parkinson’s disease.
Stress and Parkinson’s Disease
After conducting extensive research on methods that quiet symptoms, I have concluded that there is one step that helps the most. When anxiety and anxiety attacks are shut down, symptoms are significantly reduced. When anxiety flares its ugly head, symptoms become problematic. This is why I developed a three month online course to shut down anxiety so that symptoms become far less problematic.
My online course Shut Down Anxiety introduces methods, strategies and techniques that have been proven by research and practice to reduce anxiety. They turn down the volume of the overactive flight-fight sympathetic nervous system that inflames neurological difficulties.
I did not invent these techniques. They have been extracted and simplified from an extensive body of contributions by experienced practitioners and researchers. So, check out the online course and begin taking action on the methods suggested. They really will make a huge difference. Enrollment in the course is available here: Shut Down Anxiety.
Negative Thoughts Fuel Symptoms
The first online course I created focused on the transformation of thoughts that are not in our best and highest good. An explanation of the course and enrollment is available at: Five Steps to Recovery.
Stress and Parkinson’s Disease Summary
Of course symptoms of Parkinson’s can be suppressed with medications and supplement. A more direct approach that does not trigger the cost of side effects is to Shut Down Anxiety which it flares up. It also pays handsomely to transform negative thoughts that road block any recovery program by taking Five Steps to Recovery.
I was diagnosed with Parkinsons about a year ago and began treatment with levodopa about 6 months ago. Symptoms have been alleviated. I also began craniosacral therapy for Parkinsons about the same time as the levodopa. So, of course now I cannot tell which has been helpful.
My question however is about the scheduling of craniosacral massage: should I expect to have massage treatments on a periodic basis whenever symptoms worsen or should I schedule sessions on a regular basis regardless of symptoms? In other words, do conditions alleviated by craniosacral massage recur?
Thank you for all you do.
Carol
Decisions about the timing of any treatment – in this case craniosacral therapy – are in large part a function of the purpose you wish the therapy to serve. The answer is actually rooted in the thought which underpins your decision to do the therapy.
Is the purpose to alleviate symptoms? If so, the intent is not to heal the underlying cause of the symptoms. It is probably best to go when pain surfaces or symptoms flare. Recognize here that you are in a negative cycle. You have embraced the thought form that you will not get better, so the best you can do for yourself is to address symptoms as best you can.
As I write this I can feel a very low energy and energy to this plan of action. And, if this is the purpose, you will be seeing a craniosacral therapist for the rest of your life.
Is the purpose to heal the underlying cause of the symptoms? If so, the challenge is to work with a craniosacral therapist so that you can unwind and release the trauma that is trapped at the cellular level in your body. If you set your intention to heal and release the trauma, you will gradually feel better and better, though you may have setbacks here and there as your body adjusts.
Once the trauma is released and the tension in the body has been unwound, you do not have to continue getting regular treatments. Only if you are re traumatized will additional treatments be necessary.
This needs to be a gentle and gradual process, with no reason to rush or nudge it forward faster than your body can tolerate. As I write this paragraph, I can feel a very high level of energy and hope exudes every cell of my body.
How often should you go? Your body will give you the answer. Just ask it.
When it comes to decisions regarding craniosacral therapy for Parkinsons, the answer depends on the thought form that is motivating the interest in doing the therapy. Is the
expectation to supress the symptoms temporarily as is the case with medications or is
the expectation to heal the trauma that lies at the foundation of the disease.
I thought you could be interested
in seeing a short segment of my
interview with Mary (not her
real name) who offers high
praise for the benefits of exercise. She
reports exercise offers relief from symptoms of
Parkinsons.
Swimming and exercising makes
me feel great. And after I take
glutathione I can walk. I will
go through weeks were I walk
everyday at the park and I swim
and then I go through a week
where I do nothing.
I read on your site, I think it was
one of your newsletters, that
tandem bicycling was great for
Parkinsons patients. So, we
go to the park almost everyday
and rent one of those side by side
tandems. My caregiver drives it
and I pedal along. I walk much
better after that.
I do that everyday that I can. Many times we go down to the beach and rent the three-wheelers. The three-wheelers are helpful.
How much time every day
do you spend on your exercise program?”
Like an hour a day. I had a yoga person tell me that yoga helps also.
You definitely notice exercise offers relief
from symptoms of Parkinsons?
difference? When you exercise
you feel better and when you
do not exercise you feel worse?
Exactly. Definitely.
What follows is a report from Taube about her experience with exercising:
I have been increasing the intensity of my exercising and I am doing incredibly better. I just read a book called Spark by John Rately that talks about what exercising does for the brain. It is worth reading I recommend it highly. After reading the book I started increasing the intensity of my workouts and I think it has made a big impact on my recovery.
This is a detailed report from responses provided by persons with Parkinson’s symptoms who responded to the 2024 Parkinsons Recovery Survey. The two minute survey asks two questions.
First, how have respondents been feeling since the previous holiday season one year ago (better, same, worse)
Second, what therapies have offered them symptom relief.
Listen to my reading of responses that reveal a huge range of therapies, methods and activities that offer symptom relief.
Bottom line: Many people believe that all persons diagnosed with Parkinson’s disease are destined to degenerate over time. As with the results of previous years, findings from 2024 soundly refute this false belief.
When a symptom flares its ugly head and makes us feel horrible, we all would like to celebrate relief from it, even if for only a few hours. The question everyone wants the answer to is: what is wrong with me? My answer to this question will likely surprise you.
There are over 160 medical specialties and subspecialties in the United States. If you want a name for the troubling symptom you confront, which of the 160 medical specialties can answer your question? Your general practitioner will help sort this out for you and make a referral.
The visit to the medical specialty referral will likely yield a name for your condition and medicines to treat it. This may well offer welcome relief, but sometimes not. If not. a second referral is needed, then perhaps a third and a fourth, all of which reveal different names (and diagnoses) for your condition.
And please give the medical professionals a break. They are viewing your condition from a very focused lens given their specialty. They are taking into consideration only one of many systems in the body that keep us alive and well.
I for one prefer a different approach. Support the body’s ability to heal from the inside out with natural therapies and methods, regardless of what symptoms might present right now.
Instead of suppressing a symptom caused by a presumably “flawed” body, honor the ability of the body to return to a balance of balance and harmony.
What is my answer to the question posed in this post? Watch the video.
Below is an email I received from Brad which offers a fresh perspective on the meaning associated with neurological symptoms.
I got “PD’ed” at church today. I was a visitor and had no sooner entered than I was greeted by a young man with very obvious Down Syndrome. He instantly spotted my shaking hand and said with a big smile,
“Don’t worry, you don’t have to be nervous, it’s only Ash Wednesday. Or perhaps you’re very excited because you have such a beautiful wife!”
From his perspective there was absolutely nothing “wrong” with me; to the contrary everything was “right” with me. My partner and I agreed that there was a profound lesson to be learned from this man’s innocent and perceptive observation. Brad
Redox signaling is the foundation process that is required to support the health of humans, plants and animals. It is the boost needed for the body to reverse illness and sustain health.
Redox signaling supports the ability of cells to respond appropriately to environmental stimuli. When each cell acts independently of other cells, its ability to avert illness and disease is compromised. Redox cell signaling activates communication among cells to support the body’s ability to reverse illness and maintain balance and harmony.
Redox cell signaling …
Does no harm
Contains no toxins
Wakes up sleepy cells
Helps un-poison the body
Activates a natural process of healing
Has anti-viral properties
Addresses bacterial infections
Facilitate the production of glutathione by the body
Reduces reactions to chronic stress
When confronted with neurological challenges, the allostatic load becomes too great for the body to perform the functions of toxic elimination. All of the body’s elimination organs (eg: liver, kidneys, colon, skin) are confronted with getting rid of more toxins than can be processed out of the body. It is similar to when a dam overflows.
Unable to eliminate toxins, they continue to cumulate. This compromises the body’s ability to rejuvenate and regenerate. With Parkinsons, the allostatic load becomes too overwhelming for the body to perform the essential functions of elimination and renewal.
Redox cell signaling helps lower and overburden flooded with an allostatic load that has maxed out.
Research on Redox Signaling and Parkinsons
Chin Med J (Engl). 2026 Mar 5;139(5):653–671. Role of LRRK2 in physiological activities, diseases, and therapy
Abstract
Leucine-rich repeat kinase 2 (LRRK2) is a critical target for the treatment of Parkinson’s disease (PD) and potentially other diseases. LRRK2 is involved in intracellular signaling, immune response, and inflammation, with key roles in both the central nervous system and peripheral tissues.
LRRK2 mutations are linked to cellular dysfunction including mitochondrial and neuronal damage and can disrupt signaling pathway balance, thereby contributing to PD and other disorders
Research studies report that a NAD Supplement for Parkinsons can be beneficial. NAD stands for Nicotinamide Adenine Dinucleotide. Studies find that taking a NAD supplement facilitates a more effective detoxification process when compared to conventional methods. By replenishing the body’s NAD levels, toxins are flushed out and brain functions are restored.
The NAD supplement for Parkinsons …
Promotes cellular repair
Supports neuroplasticity
Improves overall functionality of the brain
Enhances memory
Sharpens concentration
Research on NAD Supplement for Parkinsons
Trends Endocrinol Metab. 2025 Dec;36(12):1072-1083. NAD augmentation as a disease-modifying strategy for neurodegeneration
Abstract
Neurodegenerative diseases (NDDs) pose a significant and rapidly growing global health challenge, but there are no effective therapies to delay or halt progression.
In recent years augmentation of nicotinamide adenine dinucleotide (NAD) has emerged as a promising disease-modifying strategy that targets multiple key disease pathways across multiple NDDs, such as mitochondrial dysfunction, energy deficits, proteostasis, and neuroinflammation.
Several early clinical trials of NAD augmentation have been completed, and many more are currently underway, reflecting the growing optimism and urgency within the field. We discuss the rationale and evolving therapeutic landscape of NAD augmentation.
******
Am J Physiol Endocrinol Metab. 2024 Apr 1;326(4):E417-E427. Evaluation of safety and effectiveness of NAD in different clinical conditions: a systematic review
Abstract
Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide cofactor that is present in cells and in several important biological processes, including oxidative phosphorylation and production of adenosine triphosphate, DNA repair, calcium-dependent secondary messenger and gene expression.
The purpose of this systematic review is to examine whether the coenzyme formulae NAD+ and NADH are safe and effective when acting as a supplement to humans. This systematic review of randomized clinical trials performed a search in six electronic databases: PubMed, MEDLINE (ovid), Embase, Cochrane CENTRAL (clinical trials), Web of Science, and Scopus. Secondary search included the databases (e.g., Clinical trials.gov, Rebec, Google Scholar – advance). Two reviewers assessed and extracted the studies independently. The risk of bias in studies was performed using version 2 of the Cochrane risk of bias tool for randomized trials. This review includes 10 studies, with a total of 489 participants. The studies included different clinical conditions, such as chronic fatigue syndrome (CFS), older adults, Parkinson’s disease, overweight, postmenopausal prediabetes, and Alzheimer’s disease.
Based on studies, the supplementation with NADH and precursors was well tolerated and observed clinical results such as, a decrease in anxiety conditions and maximum heart rate was observed after a stress test, increased muscle insulin sensitivity, insulin signaling. Quality of life, fatigue intensity, and sleep quality among others were evaluated on patients with CFS. All studies showed some side effects, thus, the most common associated with NADs use are muscle pain, nervous disorders, fatigue, sleep disturbance, and headaches. All adverse events cataloged by the studies did not present a serious risk to the health of the participants.
Overall, these findings support that the oral administration of NADH can be associated to an increase in general quality of life and improvement on health parameters (e.g., a decrease in anxiety, maximum heart rate, inflammatory cytokines in serum, and cerebrospinal fluid). NADH supplementation is safe and has a low incidence of side effects.
In a study published in 2026 posted below, we have still more evidence for the benefits of exercise for individuals experiencing the neurological challenges of Parkinsons. Results of this study found that an eight-week aerobic resistance training program improved tremor and walking endurance in patients with Parkinson’s symptoms.
NeuroRehabilitation. 2026 Apr 10:10538135261434253. Effects of an 8-Week Combined Aerobic Resistance Training on Motor Function, Functional Mobility, and Metabolic Parameters in Patients with Parkinson’s Disease: A Controlled Study
Abstract
Exercise is increasingly recognized as a key component of Parkinson’s disease (PD) management, but data on short-term combined aerobic-resistance training (ART) on motor and metabolic parameters remain limited.
In this controlled study, 28 patients with PD (median Hoehn & Yahr stage= 2, IQR 1.75-2.0) were allocated to an 8-week supervised aerobic-resistance training ART group (n= 19) or a stretching-only control group (n = 9). Training consisted of two 45-minute sessions weekly. Primary outcomes were MDS-UPDRS-III, Sit-to-Stand Test (STS), and Six-Minute Walk Test (6MWT).
Fasting laboratory parameters were exploratory given the small sample size and absence of an a priori power analysis. Between-group post-intervention differences were analyzed using ANCOVA (baseline as covariate); exploratory biochemical outcomes were controlled for multiple comparisons using Benjamini-Hochberg false discovery rate (FDR).
ART improved the MDS-UPDRS-III tremor subscore (p = 0.004) and6MWT distance (p = 0.003), with no significant effects on other motor or functional outcomes. In exploratory laboratory analyses, unadjusted between-group differences were observed for HDL cholesterol (p =0.014), vitamin D3 (p = 0.003), TSH (p = 0.042), and homocysteine (p =0.019); after FDR correction, only vitamin D3 remained significant (qFDR= 0.039). Total cholesterol, LDL, and VLDL showed non-significant decreases.
An eight-week ART program improved tremor and walking endurance inpatients with PD, while other motor outcomes remained unchanged. Exploratory changes in selected biochemical markers were detected (including a decrease in vitamin D3).
The truthful answer to the question “why is Parkinson’s disease increasing” will likely surprise you. Is it because of the increasing toxins in our environment? Not really, but that is certainly a factor. Is it because of contaminated water systems? Not really, but that too is a factor. Enough. The answer is …
If you watched my video, you were likely surprised at my answer. There is typically one and only one answer to the question – what causes Parkinson’s disease. The answer? A lack of dopamine. Everyone knows that, duh.
Take for example the Parkinson’s disease hand tremor. When the right medications or supplements and the right dose for your body that contain L-dopa are taken. the hand tremor is quieted. The L-dopa is converts to dopamine in the body. So maybe the reason Perhaps the answer to Why is Parkinson’s disease is increasing turns on the decreasing supply of L-Dopa?
End of story, right? I say wrong. Parkinson’s disease is caused by a persistent fear people cannot not shake. The fear is familiar to us all: Lack of control over everything and everyone.
Dynamics of the world spin so rapidly these days many people feel they do not control anything – not their pay check, not the addictions of family members, not the untimely deaths of family and friends, not global warming, not …
In the video I explain how to turnaround the feeling of being out of control with an example of how to react when Parkinsons disease hand tremors become problematic. Do we sit on our hands? Do we tuck them in our pocket? There is another approach.
In summary – More and more people are feeling they are out of control which is the simple and obvious reason why Parkinsons disease is increasing.
Twenty years of research and interviews with persons diagnosed with Parkinsons have unearthed a rich set of natural therapies to reverse symptoms. These discoveries are documented in my book Road to Recovery from Parkinsons Disease 2026.
This 2026 book includes the therapies and methods that have enabled others with Parkinsons to celebrate a successful journey down the road to recovery.
Just released for the price of one mocha cafe a week … everything you need to know about the causes of Parkinsons and heir treatments to manifest a successful recovery from Parkinsonsin 2026
* A new audiobook clip posted every day * Comprehensive review of causes * Coverage of therapies to treat specific causes * Overview of how successful recoveries are manifested * Proven formulas for success * Daily support that transform negative thoughts into positive ones * Cutting edge therapies that are transforming recovery in 2025 * Low monthly tuition during these challenging economic times. * Cancel anytime.
Daily recordings report what founder of Parkinsons Recovery Robert Rodgers PhD has discovered over two decades of research exclusively focused on Parkinsons. Visit the link below to learn more and register.
Two L-dopa sources for Parkinson’s disease dopamine are the prescription medication Sinemet and the over the counter supplement Mucuna. Compounding Pharmacist Randy Mentzer answers the following question:
“Can both be taken and if so can there be unwanted side effects?”
Treatment of Parkinson’s disease symptoms often involves taking medications aimed at increasing Parkinson’s disease dopamine levels in the body. Among the various treatment options, Sinemet (a combination of levodopa and carbidopa) is prescribed by doctors to help alleviate motor symptoms by replenishing dopamine.
Patients and practitioners sometimes add mucuna pruriens, a natural supplement, to the treatment regimen. While mucuna does not require a prescription from a doctor it is, like Sinemet, a medicine that contains L-dopa. The body converts the L-dopa to dopamine.
Understanding Sinemet
Sinemet is a prescribed medication for Parkinson’s disease that combines two drugs:
Levodopa: This precursor to dopamine is converted into the neurotransmitter dopamine in the brain, which is crucial for regulating movement and coordination.
Carbidopa: This component prevents levodopa from being converted into dopamine before it reaches the brain, which helps to maximize the effectiveness of levodopa and reduce side effects like nausea.
While Sinemet is effective, its impact usually diminishes over time. Patients usually need to take higher and higher doses to achieve the desired result.
Enter Mucuna Pruriens
Mucuna pruriens, often referred to as velvet bean, is a natural source of levodopa. It’s been used in traditional medicine for centuries and is now gaining attention in the context of Parkinson’s disease treatment. The beans of the mucuna plant contain L-dopa, the same compound found in Sinemet.
Potential Benefits of Combining Mucuna with Sinemet for Parkinson’s Disease Dopamine
Enhanced Dopamine Levels: Since mucuna contains l-dopa, it may potentially boost dopamine levels in the brain, complementing the effects of Sinemet. Some studies suggest that mucuna could offer a more rapid or sustained increase in dopamine levels compared to synthetic levodopa.
Reduced Motor Fluctuations: Mucuna might help in smoothing out the “on-off” fluctuations experienced by some Parkinson’s patients on Sinemet alone. The natural levodopa in mucuna might work more consistently to help manage symptoms throughout the day.
Possible Reduction in Side Effects: Some users report fewer side effects with mucuna compared to synthetic levodopa preparations. This could be due to the natural formulation of mucuna.
Considerations and Risks
Lack of Standardization: Unlike prescription medications, the potency and purity of mucuna supplements can vary widely. This lack of standardization means that the exact dose of levodopa can be unpredictable.
Drug Interactions: Mucuna may interact with Sinemet, potentially altering the effectiveness of either medication. It’s crucial to monitor any changes in symptoms and adjust dosages under medical supervision.
Side Effects: While mucuna might have fewer side effects for some, it’s not without risks. Potential side effects include dyskinesia (the side effect Randy mentions in his answer to the question posed to him above), nausea, dizziness, or digestive issues. Always discuss these possibilities with your healthcare provider.
Practical Tips for Combining Mucuna with Sinemet
Consult Your Doctor: Before introducing mucuna into your regimen, have a thorough discussion with your neurologist or primary care physician. They can provide personalized advice based on your specific condition and treatment goals.
Now here is something interesting to do, especially if you ever wondered what your voice says about you. But first – what is voice profiling?
Sound Health has discovered that the frequencies contained in the voice are holographic representations of your state of health and wellness. Every muscle, compound, process and structure of the body has a Frequency Equivalent™ that can be mathematically calculated. It is our belief that people with similar trauma, illnesses, syndromes, psychologies, diseases, toxins… have similar, if not identical, vocal anomalies.
You can obtain an analysis of your voice profile which is available on the Sound Health Portal for free. Here is the link to get a free analysis of your voice.
Once you land on the Nano Voice page above, click Start. Then, talk in a normal voice without pauses for 90 seconds. An analysis of the frequencies emitted by your voice will be instantly provided.
Once you generate your first overview report, you can restart Nano voice and talk a second time for 90 seconds to generate a follow-up report. I talked for 90 seconds three times back to back. The three reports of my personality were all very similar. I must report they also described me to a tea.
Why bother?
It is free
It takes only 5 minutes
The instant report that is generated is fascinating
This short activity will convince you to take analysis of voice profiles seriously. Healing through sound (and light) is the medicine of the future
Homocystene is an amino acid that circulates in the blood. It is produced when the body breaks down protein. Low homocysteine levels are considered healthy. Elevated levels are problematic for a number of reasons. High levels …
Are a marker of inflammation
Cause dementia
Can cause strokes
Damage artery walls
Increase blood clot risks
Compromise the cardiovascular system.
A reason homocysteine levels can be too high in the case of Parkinsons is that certain medicines delete vitamins B6, B12 and folic acid (vitamin B9). How do you reduce unusually high levels of homocysteine? Increase the intake of vitamins B6, B12 and folic acid – the ones that just happen already to be chronically deficient.
Supplements of course can be taken to supplement low levels of B vitamins. Alternatively, certain foods boost the level of B vitamins. The following foods are rich in vitamins B6, B12 and folic acid:
Spinach
Beef liver
Chicken liver
Chickpeas
Sunflower seeds
Wild salmon
Eggs
Clams
Oysters
Sardines
Lentils
Research on Homocysteine Levels and Parkinsons
Heliyon. 2024 Nov 6;10(21):e40191. Association analyses of nutritional markers with Parkinson’s disease and Alzheimer’s disease
Abstract
Introduction: Parkinson’s disease (PD) and Alzheimer’s disease (AD) are common neurodegenerative diseases with multifaceted etiology. Nutritional and metabolic abnormalities are frequently implicated in PD and AD. In this observational study, we analyzed a series of nutritional markers, and aimed to understand their association with AD and PD risk.
Methods: A total of 424 PD patients, 314 AD patients, and 388 healthy controls were included. Nutritional markers including Hemoglobin A1c, vitamin B12, folate, apolipoprotein B (ApoB), apolipoprotein A1 (ApoA1), low-density lipoprotein (LDL), high-density lipoprotein, triglyceride, total cholesterol (TC), uric acid and homocysteine (HCY) were measured. Significance for odds ratios examining was P < 0.0045 after bonferroni correction.
Results: Multifactor risk analysis showed that ApoB, LDL, and TC reduce PD risk, while homocysteine HCY increase PD risk. ApoA1 and HCY are protective and risk factors for AD, respectively.
Conclusion: The cross-sectional study demonstrates that HCY and lipid metabolism markers are associated with PD and AD risks. Our findings support the involvement of one-carbon metabolism and lipid metabolism disturbance in PD and AD.
Nutrients. 2025 Apr 11;17(8):1325. Homocysteine, Nutrition, and Gut Microbiota: A Comprehensive Review of Current Evidence and Insight
Abstract
Homocysteine, a sulfur-containing amino acid, is an intermediate product during the metabolism of methionine, a vital amino acid. An elevated concentration of homocysteine in the plasma, named hyperhomocysteinemia, has been significantly related to the onset of several diseases, including diabetes, multiple sclerosis, osteoporosis, cancer, and neurodegenerative disorders such as dementia, Alzheimer’s and Parkinson’s diseases.
An interaction between metabolic pathways of homocysteine and gut microbiota has been reported, and specific microbial signatures have been found in individuals experiencing hyperhomocysteinemia.
Furthermore, some evidence suggests that gut microbial modulation may exert an influence on homocysteine levels and related disease progression. Conventional approaches for managing hyperhomocysteinemia typically involve dietary interventions alongside the administration of supplements such as B vitamins and betaine.
The present review aims to synthesize recent advancements in understanding interventions targeted at mitigating hyperhomocysteinemia, with a particular emphasis on the role of gut microbiota in these strategies. The emerging therapeutic potential of gut microbiota has been reported for several diseases.
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.Acta Neurol Belg. 2025 Apr;125(2):435-444. Diagnostic values of serum levels of ?-synuclein, homocysteine and leucine-rich ?2 glycoprotein for predicting cognitive impairment in Parkinson’s diseas
Abstract
Background: ?-synuclein, homocysteine (Hcy) and leucine-rich ?2-glycoprotein (LRG) have been shown to correlate to Parkinson’s disease (PD). However, it remains unclear whether these factors are associated with the occurrence of cognitive impairment (CI) in PD patients.
Methods: This study initially enrolled eligible PD patients without cognitive impairment. Blood samples were collected to measure serum levels of ?-synuclein, Hcy, and LRG using enzyme-linked immunosorbent assay. After one year of treatment, patients were divided into CI group and non-CI groups based on their Montreal Cognitive Assessment (MoCA) scores. Baseline clinical characteristics and the levels of these three factors were compared between the two groups. Additionally, Receiver Operating Characteristic (ROC) analysis was used to assess the predictive value of these factors for the occurrence of CI in PD patients.
Results: The study included 102 eligible PD patients without baseline CI, divided into 65 patients in the non-CI group and 37 patients in the CI group after one year, based on the MoCA scores. Serum levels of ?-synuclein, Hcy, and LRG in the CI group were 0.42 ± 0.33 ng/mL, 19.85 ± 6.31 µmol/L, and 14.53 ± 5.11 ng/mL respectively, compared to 0.04 ± 0.03 ng/mL, 14.32 ± 5.25 µmol/L, and 11.67 ± 3.10 ng/mL in the non-CI group. Patients in the CI group had MoCA scores below 26, indicating cognitive impairment. ROC analysis revealed that ?-synuclein, Hcy, and LRG levels effectively predicted the occurrence of CI in PD patients.
Conclusions: Serum levels of ?-synuclein, homocysteine and glycoprotein were elevated in the CI group compared to the non-CI group, suggesting that these factors may serve as predictors of cognitive impairment in PD patients.
A 10 percent discount is available with coupon code healing4me. If your child does not show the improvement anticipated after 6 months of daily use, you can return the Duo device for an 80% refund
Ground Breaking Discovery for Autism Using the Vielight Neuro Duo
As the world’s only transcranial-intranasal brain photobiomodulation device, the Vielight Neuro Duo is the result of years of engineering and research.
Groundbreaking discovery for autism research with the Vielight technology produced improvements in cognition, memory and blood flow.
The Vielight Neuro Duo comes with both Alpha and Gamma modes.
Gamma (40Hz): focus, memory, brain energy.
Alpha (10 Hz): relaxation and sleep improvement.
Summary for the Autism Spectrum Disorder Clinical Study
Children (BASEL). 2022 May 20;9(5):755. Transcranial Photobiomodulation for the Treatment of Children with Autism Spectrum Disorder (ASD): A Retrospective Study
Data were reported and analyzed for 21 children, 13 males and 8 females with an average age of 9.1. The age range is 5 to 15 years old. The study was conducted over six months in the home setting.
Participants used the Vielight Neuro Duowith its two protocols, the Alpha 10 hertz protocol and the Gamma 40 hertz protocol.
Both Alpha and Gamma protocols were administered each day, one in the morning and one in the evening. Each session had a duration of 20 minutes, during which children were involved in stimulating activities such drawing, coloring, reading, playing games or doing homework.
Findings
After 6 months, transcranial-intranasal photobiomodulation was associated with:
reduction in ASD severity, as shown by a decrease in CARS scores (p < 0.001).
reduction in noncompliant behavior
reduction in parental stress
reduction in behavioral and cognitive rigidity
improvement in attentional functions and in sleep quality.
These remarkable improvements not only enhanced the lives of the patients but also greatly reduced stress among their parents, as measured by the SDAG scale, creating a more peaceful and effective environment for growth.
How Photobiomodulation Reverses Austism
How does the Vielight Neuro Duo photobiomodulation device work? It emits an optimal irradiance, amongst the highest in the industry with the 810 nanometer wavelength to penetrate the skull and reach the brain, transcranially and intranasally. The Vielight Neuro Duo’s design specifically targets the Default Mode Network to improve connectivity between its nodes.
The default mode network is crucial in understanding autism. Individuals with autism spectrum disorder have been observed to have alterations in their default mode network, contributing to difficulties in social interactions and understanding others’ perspectives.
Research has revealed that atypical connectivity within the default mode network underlies the characteristic challenges in social communication and repetitive behaviors seen in autism.
The two different pulsing modes, Alpha and Gamma have complementary effects. The alpha protocol promotes relaxation, reducing rigidity and improving sleep. The gamma protocol boosts cognitive functions which facilitates improved focus and attention.”
Safety and Future Directions
From a safety perspective the treatment has been well-tolerated with minimal side effects, making it a safe option.
The second study abstract below reports positive results for younger children ages 2-6.
Front Neurol. 2024 Apr 26:15:1221193. Transcranial photobiomodulation in children aged 2-6 years: a randomized sham-controlled clinical trial assessing safety, efficacy, and impact on autism spectrum disorder symptoms and brain electrophysiology
Abstract
Background: Small pilot studies have suggested that transcranial photobiomodulation could help reduce symptoms of neurological conditions, such as depression, traumatic brain injury, and autism spectrum disorder.
Objective: To examine the impact of photobiomodulation on the symptoms of Autism in children aged two to six years. (The study listed above is based on older subjects 5-15 years in age).
Method: This study ran a randomized, sham-controlled clinical trial involving thirty children aged two to six years with a prior diagnosis of ASD. Pulses of near-infrared light (40 Hz, 850 nm) noninvasively were delivered to selected brain areas twice a week for eight weeks, using an investigational medical device designed for this purpose. We used the Childhood Autism Rating Scale (CARS) to assess and compare the Autism symptoms of participants before and after the treatment course. Electroencephalogram data during each session were collected from participants who tolerated wearing the cap.
Results: The difference in the change in CARS scores between the two groups was 7.23 (95% CI 2.357 to 12.107, p = 0.011). Seventeen of the thirty participants completed at least two EEGs and time-dependent trends were detected. In addition, an interaction between Active versus Sham and Scaled Time was observed in delta power (Coefficient = 7.521, 95% CI -0.517 to 15.559, p = 0.07) and theta power (Coefficient = -8.287, 95% CI -17.199 to 0.626, p = 0.07), indicating a potential trend towards a greater reduction in delta power and an increase in theta power over time with treatment in the Active group, compared to the Sham group. Furthermore, there was a significant difference in the condition (Treatment vs. Sham) in the power of theta waves (net_theta) (Coefficient = 9.547, 95% CI 0.027 to 19.067, p = 0.049). No moderate or severe side effects or adverse effects were reported or observed during the trial.
Groundbreaking Discovery for Autism Conclusion:
Findings of these two studies taken together indicate that photobiomodulation is a safe and effective treatment for Autism. The Vielight Neuro Duo offers a groundbreaking treatment for Autism.
A 10 percent discount is available with coupon code healing4me. If your child does not show the improvement anticipated after 6 months of daily use, you can return the Duo device for an 80% refund.
Call Vielight to get answers to your questions. The company is located in Toronto Canada: 1-877-355-8012 (Main line)
One dominant source of toxins for persons experiencing neurological challenges is polluted drinking water. One option many people embrace is to filter the water that they drink. This is a marked improvement over drinking unfiltered tap water. But what about distilled water? I this video I offer a comparison of distilled vs filtered water.
My honest confession is that I had never considered distilled water until a few months ago when it was recommended by our naturopath doctor. My initial reaction was to wonder whether bothering to distill water every day was really worth the effort.
What is Distilled Water?
Distilled water involves boiling it into steam, then condensing the steam back to a liquid. This removes toxins, bacteria, chemicals and microbes. It does take 5-6 hours to boil a gallon of water to make distilled water. Is the bother worth it?
As I point out in the video, I am shocked every day at the residue of gunk, sludge and goop that remains in the container after the gallon of water is distilled. Oh my. I have been putting that sludge into my body all this time (which has been a few decades).
Admittedly some of the sludge that remains consists of beneficial substances like minerals. But most of the gunk is toxic. I would prefer to get the minerals my body needs from eating nutritious food rather than drinking water that is laced with toxins.
There are many distilled devices on the market. Here is the one that we have been using.
I have a heads up on the most fascinating interview below. Leif Ogard has had Parkinsons for over two decades. Leif has published a book with the quite fascinating title of I Have Parkinsons But Parkinsons Does Not Have Me.
Leif feels great – not just good – but great. Many people who do not experience symptoms of Parkinsons cannot say this! He has incredible energy and owns his own business which he started after his diagnosis.
By the way, his business is thriving. Leif considers himself healthy in every respect.
In this interview Leif offers genuinely helpful insights and suggestions. His perspectives will be especially helpful for anyone who has been recently diagnosed.
One of the testimonials for his book posted on Amazon reads:
“Leif Ogard is an engineer and consultant by profession. His meticulous attention to detail about his condition, life and attitude are inspirational. He over came his own fears and self doubts to accomplish extra ordinary feats and still does). He decided rather than be a victim, he would control his life by studying, documenting and controlling everything that influenced his body.”
If you are in a place in your life where you could use a motivational boast listen to my interview with Leif. You will not be disappointed. on Blog Talk Radi
The cover of Leif’s book is shown here. Believe me when I tell you that his life is true to the title of his book.