An abstract of a 2024 study below finds a link between gut microbes in Parkinson’s patients with decreased levels of two B vitamins: riboflavin ( vitamin B2) and biotin (vitamin B7). Researchers recommend patients supplement Vitamins B2 and B7 for Parkinson’s.

Research shows there is a strong link between the health of our gut and Parkinson’s symptoms.

Researchers have long recommended patients discuss with their doctor the supplementation of B1, B5 and B12 vitamins, largely because medications cause their gradual depletion. This recent study adds to the list of two additional B vitamins: B2 and B7.

Supplementation is possible from eating certain foods as well as taking supplements. Many foods contain B2 (spinach is one) and B7 (such as eggs and salmon)

A deficiency B vitamins has been correlated with a decrease in short-chain fatty acids. These are the molecules that create a healthy mucus layer in the intestines. This leads to a thinning of the mucus layer in the intestines which in turn increases intestinal permeability.

A compromised intestinal layer exposes the nervous system to be assaulted by toxins such as cleaning chemicals, pesticides, and herbicides. This is why toxins are one of the primary causes of Parkinson’s symptoms and why detox protocols are fundamental to a successful recovery.

Below is an Abstract of the Recent Study

NPJ Parkinsons Dis. 2024 May 21;10(1):106. Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease

Abstract

We aimed to identify gut microbial features in Parkinson’s disease (PD) across countries by meta-analyzing our fecal shotgun sequencing dataset of 94 PD patients and 73 controls in Japan with five previously reported datasets from USA, Germany, China1, China2, and Taiwan. GC-MS and LC-MS/MS assays were established to quantify fecal short-chain fatty acids (SCFAs) and fecal polyamines, respectively. ?-Diversity was increased in PD across six datasets.

Taxonomic analysis showed that species Akkermansia muciniphila was increased in PD, while species Roseburia intestinalis and Faecalibacterium prausnitzii were decreased in PD. Pathway analysis showed that genes in the biosyntheses of riboflavin and biotin were markedly decreased in PD after adjusting for confounding factors. Five out of six categories in carbohydrate-active enzymes (CAZymes) were decreased in PD. Metabolomic analysis of our fecal samples revealed that fecal SCFAs and polyamines were significantly decreased in PD. Genes in the riboflavin and biotin biosyntheses were positively correlated with the fecal concentrations of SCFAs and polyamines.

Bacteria that accounted for the decreased riboflavin biosynthesis in Japan, the USA, and Germany were different from those in China1, China2, and Taiwan. Similarly, different bacteria accounted for decreased biotin biosynthesis in the two country groups.

Why to supplement vitamins B2 and B7 for Parkinson’s

Decreased SCFAs and polyamines reduce the intestinal mucus layer, which subsequently facilitates the formation of abnormal synuclein fibrils in the intestinal neural plexus in Parkinson’s patients. This causes and neuro-inflammation in and compromises the ability of the body to eliminate toxins.